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Article

Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis.

Circulation - 10 Oct 2000

Guzik T J, West N E, Black E, McDonald D, Ratnatunga C, Pillai R, Channon K M

Abstract excerpt

BACKGROUND: Increased superoxide anion production increases oxidative stress and reduces nitric oxide bioactivity in vascular disease states. NAD(P)H oxidase is an important source of superoxide in human blood vessels, and some studies suggest a possible association between polymorphisms in the N...

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Source

Identifiers

PMID: 11023926
DOI: 10.1161/01.cir.102.15.1744

Genes

CYBA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11023926-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis.PMID 11023926Read ↗

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The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia.Semantic proximity Read ↗

C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.Semantic proximity Read ↗

The C242T polymorphism of the p22phox component of NAD(P)H oxidase and vascular risk. Two case-control studies and a meta-analysis.Semantic proximity Read ↗

Oxidative stress and cardiovascular risk: the role of vascular NAD(P)H oxidase and its genetic variants.Semantic proximity Read ↗

The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease.Semantic proximity Read ↗

CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study.Semantic proximity Read ↗

The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia.Semantic proximity Read ↗

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