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Article

Impact of NAD(P)H oxidase p22 phox gene polymorphism on vascular aging in Korean centenarian and nonagenarian.

International journal of cardiology - 15 Dec 2007

Kim Kwang-Il, Na Jung-Eun, Kang Seo Young, Cho Young-Seok, Choi Dong-Ju, Kim Cheol-Ho, Kim Hyo-Soo, Oh Byung-Hee, Choi Yoon-Ho, Kwon In Soon, Park Sang-Chul

Abstract excerpt

BACKGROUND: Oxidative stress, the imbalance between production and removal of reactive oxygen species (ROS), is implicated in the process of cardiovascular aging. Membrane-associated NAD(P)H oxidase system is the most important source of ROS in vascular cells. p22(phox), a critical component of the NAD(P)H oxidase, has a polymorphic site on exon 4, associated with variable enzyme activity. The goal of this study...

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PMID: 17307262
DOI: 10.1016/j.ijcard.2006.11.105

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