Article
The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.
Pharmacogenetics and genomics - 1 Oct 2008
Veeramah Krishna R, Thomas Mark G, Weale Michael E, Zeitlyn David, Tarekegn Ayele, Bekele Endashaw, Mendell Nancy R, Shephard Elizabeth A, Bradman Neil, Phillips Ian R
Abstract excerpt
BACKGROUND: The drug-metabolizing enzyme flavin-containing monooxygenase 2 (FMO2) is the predominant FMO isoform present in the lung of most mammals, including non-human primates. All Europeans and Asians tested have been shown to be homozygous for a non-functional variant, FMO2*2A, which contains a premature stop codon due to a single-nucleotide change in exon 9 (g.23238C>T). The ancestral allele, FMO2*1,...
Topics
- Adolescent
- Africa South of the Sahara
- Alleles
- Chromosome Mapping
- Gene Frequency
- Genetic Variation
- Genotype
- Haplotypes
- Humans
- Likelihood Functions
- Lung
- Male
- Mutation