Article
Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2004
Krueger Sharon K, Siddens Lisbeth K, Martin Sarah R, Yu Zhen, Pereira Clifford B, Cabacungan Erwin T, Hines Ronald N, Ardlie Kristin G, Raucy Judy L, Williams David E
Abstract excerpt
A polymorphism for the phase I drug-metabolizing enzyme, flavin-containing monooxygenase isoform 2 (FMO2), encoding either truncated inactive protein, FMO2X472 (FMO2.2A), or full-length active enzyme, FMO2Q472 (FMO2.1), is known and exhibits significant interethnic differences in allelic frequency. FMO2 is the major or sole FMO isoform expressed in the lung of most mammals, including nonhuman primates. To date,...
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