Article
Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.
Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2003
Furnes Bjarte, Feng Jinong, Sommer Steve S, Schlenk Daniel
Abstract excerpt
Sequence polymorphisms in enzymes involved in drug metabolism have been widely implicated in the differences observed in the sensitivity to various xenobiotics. The flavin-containing monooxygenase (FMO) gene family in humans catalyzes the monooxygenation of numerous N-, P- and S-containing drugs, pesticides, and environmental toxicants. Six genes (FMO1-6) have been identified so far, but the major alleles of FMO2...
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