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Article

Genetic polymorphisms of flavin-containing monooxygenase (FMO).

Drug metabolism reviews - 1 Aug 2002

Krueger Sharon K, Williams David E, Yueh Mei-Fei, Martin Sarah R, Hines Ronald N, Raucy Judy L, Dolphin Colin T, Shephard Elizabeth A, Phillips Ian R

Abstract excerpt

Mammalian flavin-containing monooxygenase (FMO) exists as six gene families and metabolizes a plethora of drugs and xenobiotics. The major FMO in adult human liver, FMO3, is responsible for trimethylamine (TMA) N-oxygenation. A number of FMO3 mutant alleles have been described and associated with a disease termed trimethylaminuria (TMAU). The TMAU patient excretes large amounts of TMA in urine and sweat. A more...

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Source

Identifiers

PMID: 12214664
DOI: 10.1081/dmr-120005653

Genes

FMO2
FMO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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