Article
Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics.
Pharmacogenetics and genomics - 1 Apr 2005
Krueger Sharon K, Siddens Lisbeth K, Henderson Marilyn C, Andreasen Eric A, Tanguay Robert L, Pereira Clifford B, Cabacungan Erwin T, Hines Ronald N, Ardlie Kristin G, Williams David E
Abstract excerpt
OBJECTIVES: Previous work defined two flavin-containing monooxygenase 2 (FMO2) alleles. The major allele, FMO2*2 (g.23,238C>T), encodes truncated inactive protein (p.X472) whereas the minor allele, FMO2*1, present in African- and Hispanic-American populations, encodes active protein (p.Q472). Recently, four common (27 to 51% incidence) FMO2 single nucleotide polymorphisms (SNPs) were detected in African-Americans...
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