Article
Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres.
Neuron - 1 Jun 1995
Xuan S, Baptista C A, Balas G, Tao W, Soares V C, Lai E
Abstract excerpt
We generated mice with a null mutation of the forebrain-restricted transcription factor BF-1 to examine its function in brain development. Heterozygous animals have an apparently normal phenotype. Homozygous null BF-1 mutants die at birth and have a dramatic reduction in the size of the cerebral...
Topics
- Animals
- Base Sequence
- Brain
- Cell Differentiation
- Cell Division
- Cerebral Cortex
- DNA-Binding Proteins
- Epithelial Cells
- Epithelium
- Forkhead Transcription Factors
- Heterozygote
- Homozygote
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Nerve Tissue Proteins