Article
Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.
Cancer research - 15 Sept 2008
Yang Kan, Popova Natalia V, Yang Wan Cai, Lozonschi Ioanna, Tadesse Selam, Kent Scott, Bancroft Laura, Matise Ilze, Cormier Robert T, Scherer Stefan J, Edelmann Winfried, Lipkin Martin, Augenlicht Leonard, Velcich Anna
Abstract excerpt
Somatic mutations of the adenomatous polyposis coli (APC) gene are initiating events in the majority of sporadic colon cancers. A common characteristic of such tumors is reduction in the number of goblet cells that produce the mucin MUC2, the principal component of intestinal mucus. Consistent with these observations, we showed that Muc2 deficiency results in the spontaneous development of tumors along the entire...
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