Article
A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration.
Development (Cambridge, England) - 1 Apr 1991
Conlon F L, Barth K S, Robertson E J
Abstract excerpt
A genetic screen of transgenic mouse strains, carrying multiple copies of an MPSV neo retroviral vector, has led to the identification of a recessive embryonic lethal mutation, termed 413.d. This mutation is associated with a single proviral insertion and when homozygous, results in the failure o...
Topics
- Animals
- Blotting, Southern
- Cell Differentiation
- Cell Line
- Chimera
- Embryo, Mammalian
- Genes, Lethal
- Genes, Recessive
- Mice
- Mice, Transgenic
- Mutagenesis, Insertional
- Mutation
- Retroviridae
- Stem Cells