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Article

Early embryonic lethality in genetically engineered mice: diagnosis and phenotypic analysis.

Veterinary pathology - 1 Jan 2012

Papaioannou V E, Behringer R R

Abstract excerpt

Embryonic lethality is a common phenotype that occurs in mice that are homozygous for genetically engineered mutations. These phenotypes highlight the time and place that a gene is first required during embryogenesis. Early embryonic lethality (ie, before and up to mid-gestation) can be straightforward to analyze because the stage at which death occurs suggests why an embryo has failed. Here we summarize general...

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Identifiers

PMID: 21233329
DOI: 10.1177/0300985810395725
PMCID: PMC3134574

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Source receipt: pubmed, retrieved 7 Sept 2026.

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