Early embryonic lethality in genetically engineered mice: diagnosis and phenotypic analysis.

Abstract excerpt

Embryonic lethality is a common phenotype that occurs in mice that are homozygous for genetically engineered mutations. These phenotypes highlight the time and place that a gene is first required during embryogenesis. Early embryonic lethality (ie, before and up to mid-gestation) can be straightforward to analyze because the stage at which death occurs suggests why an embryo has failed. Here we summarize general...

Topics

• Animals
• Embryonic Development
• Female
• Fetal Death
• Genes, Lethal
• Genetic Engineering
• Mice
• Mice, Transgenic
• Models, Animal
• Mutation
• Phenotype
• Pregnancy