Article
Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids.
Stem cells (Dayton, Ohio) - 1 Jan 2004
Hochepied Tino, Schoonjans Luc, Staelens Jan, Kreemers Veerle, Danloy Sophie, Puimège Leen, Collen Désiré, Van Roy Frans, Libert Claude
Abstract excerpt
Embryonic stem (ES) cells, which can differentiate into almost all types of cells, have been derived from the house mouse Mus musculus, rat, rabbit, humans, and other species. Transmission of the genotype to the offspring of chimeras has been achieved only with M. musculus ES cells, limiting targeted mutagenesis using ES cells to this species. Mus spretus, which exhibits many genetic polymorphisms with M....
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