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Article

Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.

Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 2006

Wong Ma-Li, Whelan Fiona, Deloukas Panagiotis, Whittaker Pamela, Delgado Marcos, Cantor Rita M, McCann Samuel M, Licinio Julio

Abstract excerpt

Cyclic nucleotide phosphodiesterases (PDEs) constitute a family of enzymes that degrade cAMP and cGMP. Intracellular cyclic nucleotide levels increase in response to extracellular stimulation by hormones, neurotransmitters, or growth factors and are down-regulated through hydrolysis catalyzed by PDEs, which are therefore candidate therapeutic targets. cAMP is a second messenger implicated in learning, memory, and...

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Identifiers

PMID: 17008408
DOI: 10.1073/pnas.0602795103
PMCID: PMC1581426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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