Article
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science (New York, N.Y.) - 18 Nov 2005
Millar J Kirsty, Pickard Benjamin S, Mackie Shaun, James Rachel, Christie Sheila, Buchanan Sebastienne R, Malloy M Pat, Chubb Jennifer E, Huston Elaine, Baillie George S, Thomson Pippa A, Hill Elaine V, Brandon Nicholas J, Rain Jean-Christophe, Camargo L Miguel, Whiting Paul J, Houslay Miles D, Blackwood Douglas H R, Muir Walter J, Porteous David J
Abstract excerpt
The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene encoding phosphodiesterase 4B (PDE4B) is disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness. The PDEs inactivate adenosine 3',5'-monophosphate (cAMP), a...
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