Article
Distinctively lower DISC1 mRNA levels in patients with schizophrenia, especially in those with higher positive, negative, and depressive symptoms.
Pharmacology, biochemistry, and behavior - 1 Feb 2022
Chen Yu-Ming, Lin Chieh-Hsin, Lane Hsien-Yuan
Abstract excerpt
BACKGROUND: The issue of genetic influence on schizophrenia has received considerable attention. The DISC1 gene has been shown in several studies to play a role in the pathophysiology of schizophrenia. However, the relationship between DISC1 mRNA expression vs. schizophrenia and its clinical symptoms is uncertain. METHODS: Fifty-six subjects (32 patients with schizophrenia and 24 healthy controls) were enrolled....
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