Article
Genome-wide time-to-event analysis on smoking progression stages in a family-based study.
Brain and behavior - 1 May 2016
He Liang, Pitkäniemi Janne, Heikkilä Kauko, Chou Yi-Ling, Madden Pamela A F, Korhonen Tellervo, Sarin Antti-Pekka, Ripatti Samuli, Kaprio Jaakko, Loukola Anu
Abstract excerpt
BACKGROUND: Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time-to-event genome-wide association studies aiming to identify underpinning genes that accelerate or delay these transitions...
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