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The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas

9 Sept 2008

Abstract excerpt

INTRODUCTION: Breast cancers can be classified using whole genome expression into distinct subtypes that show differences in prognosis. One of these groups, the basal-like subtype, is poorly differentiated, highly metastatic, genomically unstable, and contains specific genetic alterations such as the loss of tumour protein 53 (TP53). The loss of the retinoblastoma tumour suppressor encoded by the RB1 locus is a...

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PMID: 18782450
DOI: 10.1186/bcr2142

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