Article
Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers.
Breast cancer research : BCR - 1 Jan 2010
Tung Nadine, Miron Alexander, Schnitt Stuart J, Gautam Shiva, Fetten Katharina, Kaplan Jennifer, Yassin Yosuf, Buraimoh Ayodele, Kim Ji-Young, Szász Attila M, Tian Ruiyang, Wang Zhigang C, Collins Laura C, Brock Jane, Krag Karen, Legare Robert D, Sgroi Dennis, Ryan Paula D, Silver Daniel P, Garber Judy E, Richardson Andrea L
Abstract excerpt
INTRODUCTION: The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers and reflects the cell of origin of these tumors. However, approximately 20% of breast cancers that develop in BRCA1 carriers are ER-positive (ER+); these cancers are more likely to develop as...
Topics
- Age Factors
- Biomarkers, Tumor
- Breast Neoplasms
- DNA Methylation
- ErbB Receptors
- Female
- Genes, BRCA1
- Humans
- Keratins