Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pan-cancer molecular analysis of the RB tumor suppressor pathway

2 Apr 2020

Abstract excerpt

The retinoblastoma tumor suppressor gene (RB1) plays a critical role in coordinating multiple pathways that impact cancer initiation, disease progression, and therapeutic responses. Here we probed molecular features associated with the RB-pathway across 31 tumor-types. While the RB-pathway has been purported to exhibit multiple mutually exclusive genetic events, only RB1 alteration is mutually exclusive with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Breast Cancer Therapies
Share to Cancer-related Molecular Pathways
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32242058
DOI: 10.1038/s42003-020-0873-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pan-cancer molecular analysis of the RB tumor suppressor pathwayPMID 32242058Read ↗

Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted TherapySemantic proximity Read ↗

Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted TherapySemantic proximity Read ↗

RB-pathway disruption in breast cancerSemantic proximity Read ↗

RB in Breast Cancer: The Crossroads of Tumorigenesis and TreatmentSemantic proximity Read ↗

Proteogenomic discovery of <i>RB1</i> -defective phenocopy in cancer predicts disease outcome, response to treatment, and therapeutic targetsSemantic proximity Read ↗

A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer.Semantic proximity Read ↗

Targeting the RB-pathway in Cancer TherapySemantic proximity Read ↗

High-Level MYCN-Amplified RB1-Proficient Retinoblastoma Tumors Retain Distinct Molecular SignaturesSemantic proximity Read ↗

Targeting RB1 Loss in CancersSemantic proximity Read ↗

Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell LinesSemantic proximity Read ↗

Differential impact of RB status on E2F1 reprogramming in human cancerSemantic proximity Read ↗

RB1 dual role in proliferation and apoptosis: Cell fate control and implications for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.