Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes.

Gynecologic oncology - 1 Mar 2013

Pennington Kathryn P, Wickramanayake Anneka, Norquist Barbara M, Pennil Christopher C, Garcia Rochelle L, Agnew Kathy J, Taniguchi Toshiyasu, Welcsh Piri, Swisher Elizabeth M

Abstract excerpt

OBJECTIVES: 53BP1, a critical mediator of the DNA damage response, functions by regulating the balance between homologous recombination (HR) and the more error-prone non-homologous endjoining (NHEJ). Deletion of 53BP1 in brca1 (but not brca2) null cells partially restores HR and reverses sensitivity to poly-ADP-ribose polymerase inhibitors (PARPi). We characterized 53BP1 and BRCA1 expression and their association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fallopian Tube Neoplasms

Share to Intracellular Signaling Peptides and Proteins

Share to Neoplasm Recurrence, Local

Share to Ovarian Neoplasms

Share to Peritoneal Neoplasms

Share to Tumor Suppressor p53-Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23246380
DOI: 10.1016/j.ygyno.2012.12.007
PMCID: PMC3889639

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes.PMID 23246380Read ↗

Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas.Semantic proximity Read ↗

BRCA1 Immunohistochemistry in a Molecularly Characterized Cohort of Ovarian High-Grade Serous CarcinomasSemantic proximity Read ↗

The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer.Semantic proximity Read ↗

Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers.Semantic proximity Read ↗

BRCA Mutations, Homologous DNA Repair Deficiency, Tumor Mutational Burden, and Response to Immune Checkpoint Inhibition in Recurrent Ovarian CancerSemantic proximity Read ↗

The performance of BRCA1 immunohistochemistry for detecting germline, somatic, and epigenetic BRCA1 loss in high-grade serous ovarian cancerSemantic proximity Read ↗

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalitiesSemantic proximity Read ↗

Clinical characteristics and outcomes of patients with BRCA1 or RAD51C methylated versus mutated ovarian carcinoma.Semantic proximity Read ↗

Loss of BRCA1 protein expression as indicator of the BRCAness phenotype is associated with favorable overall survival after complete resection of sporadic ovarian cancer.Semantic proximity Read ↗

BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease RecurrenceSemantic proximity Read ↗

Molecular profiles of BRCA1-associated ovarian cancer treated by platinum-based therapy: Analysis of primary, residual and relapsed tumors.Semantic proximity Read ↗

Loss of BRCA1 promotor hypermethylation in recurrent high-grade ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.