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Article

RB1 Genetic Alterations in Estrogen Receptor-Positive Breast Carcinomas: Correlation With Neuroendocrine Differentiation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2024

Schwartz Christopher J, Marra Antonio, Selenica Pier, Gazzo Andrea, Tan Kiki, Ross Dara, Razavi Pedram, Chandarlapaty Sarat, Weigelt Britta, Reis-Filho Jorge S, Brogi Edi, Pareja Fresia, Wen Hannah Y

Abstract excerpt

Genetic alterations in the retinoblastoma susceptibility gene (RB1) are present in up to 40% of triple-negative breast cancers (BCs) and frequent in tumors with neuroendocrine differentiation, including small cell neuroendocrine carcinoma. Data on RB1 genetic alterations in estrogen receptor (ER)-positive BCs are scarce. In this study, we sought to define the morphologic, immunohistochemical, and genetic features...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Neuroendocrine

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Share to Loss of Heterozygosity

Share to Receptors, Estrogen

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Source

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Identifiers

PMID: 38897452
DOI: 10.1016/j.modpat.2024.100541
PMCID: PMC11344677

Genes

RB1
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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