The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.

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Article

The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.

Cancer research - 15 May 1992

Borg A, Zhang Q X, Alm P, Olsson H, Sellberg G

Abstract excerpt

The significance of the retinoblastoma gene (RB) in the development of human breast cancer remains unclear. In the present study, loss of heterozygosity (LOH) in RB was found in 26% of 90 informative primary breast tumors and was correlated to DNA nondiploidy, a high S-phase fraction, and LOH at...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Breast Neoplasms
Chromosome Deletion
DNA, Neoplasm
Diploidy
Female
Gene Expression
Gene Expression Regulation, Neoplastic
Genes, Retinoblastoma
Heterozygote
Humans
Male
Middle Aged
Retinoblastoma Protein
S Phase

Source

Open in PubMed

Identifiers

PMID: 1581913

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1581913-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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