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Article

The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.

Cancer research - 15 May 1992

Borg A, Zhang Q X, Alm P, Olsson H, Sellberg G

Abstract excerpt

The significance of the retinoblastoma gene (RB) in the development of human breast cancer remains unclear. In the present study, loss of heterozygosity (LOH) in RB was found in 26% of 90 informative primary breast tumors and was correlated to DNA nondiploidy, a high S-phase fraction, and LOH at chromosome 17p13.3. However, allele loss was not associated with loss of RB protein (pRB) expression. Low to absent...

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PMID: 1581913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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