Article
KRAS and BRAF mutations and MSI status in precursor lesions of colorectal cancer detected by colonoscopy.
Oncology reports - 1 Oct 2014
Yamane L S, Scapulatempo-Neto C, Alvarenga L, Oliveira C Z, Berardinelli G N, Almodova E, Cunha T R, Fava G, Colaiacovo W, Melani A, Fregnani J H, Reis R M, Guimarães D P
Abstract excerpt
Colorectal cancer (CRC) is one of the most frequent cancers worldwide. Adenoma is the main precursor lesion and, recently, the serrated polyps were described as a group of colorectal lesions with malignant potential. The morphologic and biologic characterizations of serrated polyps remain limited. The aim of the present study was to determine the frequency of KRAS and BRAF mutations and microsatellite instability...
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