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Article

Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma.

Histopathology - 1 Apr 2011

Stefanius Karoliina, Ylitalo Laura, Tuomisto Anne, Kuivila Rami, Kantola Tiina, Sirniö Päivi, Karttunen Tuomo J, Mäkinen Markus J

Abstract excerpt

AIMS: To define the occurrence of KRAS and BRAF mutations, microsatellite instability (MSI), and MGMT and hMLH1 methylation and expression in colorectal serrated adenocarcinoma. METHODS AND RESULTS: KRAS codon 12/13 and 59/61 and BRAF V600E mutations, MSI, and MGMT and hMLH1 methylation and expression in 42 serrated adenocarcinomas and 17 serrated adenomas were compared with those in 59 non-serrated colorectal...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
Female
Humans
Male
Microsatellite Instability
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21457162
DOI: 10.1111/j.1365-2559.2011.03821.x
PMCID: PMC3107946

Genes

KRAS
BRAF
MGMT

Variants

Provenance

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