Article
Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients.
Human mutation - 1 Nov 2008
Enya Mayumi, Horikawa Yukio, Kuroda Eiji, Yonemaru Kayoko, Tonooka Naoko, Tomura Hideaki, Oda Naohisa, Yokoi Norihide, Yamagata Kazuya, Shihara Nobuyuki, Iizuka Katsumi, Saibara Toshiji, Seino Susumu, Takeda Jun
Abstract excerpt
Mutations in the small heterodimer partner gene (NR0B2; alias SHP) are associated with high birth weight and mild obesity in Japanese children. SHP mutations may also be associated with later obesity and insulin resistance syndrome that induces diabetes. To investigate this possibility, the prevalence of SHP mutations in Japanese with and without type 2 diabetes mellitus and the functional properties of the...
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