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Article

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.

Genes & development - 15 Apr 2009

Miao Ji, Xiao Zhen, Kanamaluru Deepthi, Min Gyesik, Yau Peter M, Veenstra Timothy D, Ellis Ewa, Strom Steve, Suino-Powell Kelly, Xu H Eric, Kemper Jongsook Kim

Abstract excerpt

Small Heterodimer Partner (SHP) inhibits activities of numerous transcription factors involved in diverse biological pathways. As an important metabolic regulator, SHP plays a key role in maintaining cholesterol and bile acid homeostasis by inhibiting cholesterol conversion to bile acids. While SHP gene induction by increased bile acids is well established, whether SHP activity is also modulated remains unknown....

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Source

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Identifiers

PMID: 19390091
DOI: 10.1101/gad.1773909
PMCID: PMC2675865

Genes

FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.PMID 19390091Read ↗

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