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Article

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2004

Kim Joon-Young, Chu Khoi, Kim Han-Jong, Seong Hyun-A, Park Ki-Cheol, Sanyal Sabyasachi, Takeda Jun, Ha Hyunjung, Shong Minho, Tsai Ming-Jer, Choi Hueng-Sik

Abstract excerpt

Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that lacks a conventional DNA binding domain (DBD) and represses the transcriptional activity of various nuclear receptors. In this study, we examined the novel cross talk between SHP and BETA2/NeuroD, a basic helix-loop-helix transcription factor. In vitro and in vivo protein interaction studies showed that SHP physically interacts...

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Identifiers

PMID: 14752053
DOI: 10.1210/me.2003-0311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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