Article
Role of nuclear receptor SHP in metabolism and cancer.
Biochimica et biophysica acta - 1 Aug 2011
Zhang Yuxia, Hagedorn Curt H, Wang Li
Abstract excerpt
Small heterodimer partner (SHP, NR0B2) is a unique member of the nuclear receptor (NR) superfamily that contains the dimerization and ligand-binding domain found in other family members, but lacks the conserved DNA-binding domain. The ability of SHP to bind directly to multiple NRs is crucial for its physiological function as a transcriptional inhibitor of gene expression. A wide variety of interacting partners...
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