Article
Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner.
Molecular and cellular biology - 1 Apr 2011
Kanamaluru Deepthi, Xiao Zhen, Fang Sungsoon, Choi Sung-E, Kim Dong-Hyun, Veenstra Timothy D, Kemper Jongsook Kim
Abstract excerpt
Small Heterodimer Partner (SHP) inhibits numerous transcription factors that are involved in diverse biological processes, including lipid and glucose metabolism. In response to increased hepatic bile acids, SHP gene expression is induced and the SHP protein is stabilized. We now show that the activity of SHP is also increased by posttranslational methylation at Arg-57 by protein arginine methyltransferase 5...
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