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Article

Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner.

Journal of lipid research - 1 Dec 2011

Park Young Joo, Kim Seong Chul, Kim Jeehee, Anakk Sayeepriyadarshini, Lee Jae Man, Tseng Hsiu-Ting, Yechoor Vijay, Park Junchol, Choi June-Seek, Jang Hak Chul, Lee Ki-Up, Novak Colleen M, Moore David D, Lee Yoon Kwang

Abstract excerpt

Mixed background SHP(-/-) mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1α expression in brown adipocytes. However, congenic SHP(-/-) mice on the C57BL/6 background showed normal expression of PGC-1α and other genes involved in brown adipose tissue thermogenesis. Thus, we reinvestigated the impact of small heterodimer partner (SHP) deletion on diet-induced...

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Identifiers

PMID: 21949050
DOI: 10.1194/jlr.M016048
PMCID: PMC3220290

Genes

PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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