Article
Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
Diabetes - 1 May 2003
Mitchell Simon M S, Weedon Michael N, Owen Katharine R, Shields Beverley, Wilkins-Wall Beverley, Walker Mark, McCarthy Mark I, Frayling Timothy M, Hattersley Andrew T
Abstract excerpt
The orphan receptor small heterodimer partner (SHP, NR0B2) modulates the transcription activity of the MODY1 gene HNF4a. Mutations in SHP were found in 7% of Japanese obese young-onset type 2 diabetic patients and were associated with moderate obesity and increased birth weight. We investigated SHP in 1927 U.K. subjects, examining relationships with type 2 diabetes, obesity, and birth weight. Sequencing of the...
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