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Article

Small heterodimer partner blocks cardiac hypertrophy by interfering with GATA6 signaling.

Circulation research - 15 Aug 2014

Nam Yoon Seok, Kim Yoojung, Joung Hosouk, Kwon Duk-Hwa, Choe Nakwon, Min Hyun-Ki, Kim Yong Sook, Kim Hyung-Seok, Kim Don-Kyu, Cho Young Kuk, Kim Yong-Hoon, Nam Kwang-Il, Choi Hyoung Chul, Park Dong Ho, Suk Kyoungho, Lee In-Kyu, Ahn Youngkeun, Lee Chul-Ho, Choi Hueng-Sik, Eom Gwang Hyeon, Kook Hyun

Abstract excerpt

RATIONALE: Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that lacks a conventional DNA-binding domain. Through interactions with other transcription factors, SHP regulates diverse biological events, including glucose metabolism in liver. However, the role of SHP in adult heart diseases has not yet been demonstrated. OBJECTIVE: We aimed to investigate the role of SHP in adult heart...

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Source

Identifiers

PMID: 25015078
DOI: 10.1161/CIRCRESAHA.115.304388

Genes

GATA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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