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Article

Hepatic inflammation facilitates transcription-associated mutagenesis via AID activity and enhances liver tumorigenesis.

Carcinogenesis - 1 Aug 2015

Matsumoto Tomonori, Shimizu Takahiro, Nishijima Norihiro, Ikeda Atsuyuki, Eso Yuji, Matsumoto Yuko, Chiba Tsutomu, Marusawa Hiroyuki

Abstract excerpt

Chronic inflammation triggers the aberrant expression of a DNA mutator enzyme, activation-induced cytidine deaminase (AID), and contributes to tumorigenesis through the accumulation of genetic aberrations. To gain further insight into the inflammation-mediated genotoxic events required for carcinogenesis, we examined the role of chronic inflammation in the emergence of genetic aberrations in the liver with...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to Dose-Response Relationship, Drug

Share to Early Growth Response Protein 1

Share to Hepatitis, Chronic

Share to Liver Neoplasms

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Source

Identifiers

PMID: 25969143
DOI: 10.1093/carcin/bgv065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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