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Article

Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations.

Cancer research - 15 Aug 2015

Sawai Yugo, Kodama Yuzo, Shimizu Takahiro, Ota Yuji, Maruno Takahisa, Eso Yuji, Kurita Akira, Shiokawa Masahiro, Tsuji Yoshihisa, Uza Norimitsu, Matsumoto Yuko, Masui Toshihiko, Uemoto Shinji, Marusawa Hiroyuki, Chiba Tsutomu

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) develops via an accumulation of various gene mutations. The mechanism underlying the mutations in PDAC development, however, is not fully understood. Recent insight into the close association between the mutation pattern of various cancers and specific mutagens led us to investigate the possible involvement of activation-induced cytidine deaminase (AID), a DNA editing...

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PMID: 26113087
DOI: 10.1158/0008-5472.CAN-14-3028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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