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Article

Involvement of activation-induced cytidine deaminase in skin cancer development.

The Journal of clinical investigation - 1 Apr 2016

Nonaka Taichiro, Toda Yoshinobu, Hiai Hiroshi, Uemura Munehiro, Nakamura Motonobu, Yamamoto Norio, Asato Ryo, Hattori Yukari, Bessho Kazuhisa, Minato Nagahiro, Kinoshita Kazuo

Abstract excerpt

Most skin cancers develop as the result of UV light-induced DNA damage; however, a substantial number of cases appear to occur independently of UV damage. A causal link between UV-independent skin cancers and chronic inflammation has been suspected, although the precise mechanism underlying this association is unclear. Here, we have proposed that activation-induced cytidine deaminase (AID, encoded by AICDA) links...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26974156
DOI: 10.1172/JCI81522
PMCID: PMC4811119

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AICDA

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