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Article

Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.

Gastroenterology - 1 May 2004

Calvisi Diego F, Factor Valentina M, Ladu Sara, Conner Elizabeth A, Thorgeirsson Snorri S

Abstract excerpt

BACKGROUND & AIMS: Human liver cancer can be divided into 2 categories that are characterized by activation of beta-catenin and genomic instability. Here we investigate whether similar categories exist among 5 transgenic models of liver cancer, including c-myc, transforming growth factor-alpha, E2F-1, c-myc/transforming growth factor-alpha, and c-myc/E2F-1 mice. METHODS: The random amplified polymorphic DNA...

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Identifiers

PMID: 15131798
DOI: 10.1053/j.gastro.2004.02.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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