Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients

9 Sept 2008

Abstract excerpt

The cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis. Using immunohistochemistry, we performed a retrospective study on 426 archival breast cancer samples from patients with long-term follow-up and compared the protein expression levels of PTK6, the HER...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to HER2/EGFR in Cancer Research
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18781181
DOI: 10.1038/sj.bjc.6604660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patientsPMID 18781181Read ↗

Targeting protein tyrosine kinase 6 in cancer.Semantic proximity Read ↗

Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling.Semantic proximity Read ↗

PTK6 Regulates IGF-1-Induced Anchorage-Independent SurvivalSemantic proximity Read ↗

KLK6‐regulated miRNA networks activate oncogenic pathways in breast cancer subtypesSemantic proximity Read ↗

Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution.Semantic proximity Read ↗

Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate RecognitionSemantic proximity Read ↗

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.Semantic proximity Read ↗

Protein tyrosine kinase-6 is post-translationally regulated by arginine methylation and ubiquitination.Semantic proximity Read ↗

Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells.Semantic proximity Read ↗

Structural and functional analysis of pp70S6k.Semantic proximity Read ↗

Metastatic effect of LY-6K gene in breast cancer cellsSemantic proximity Read ↗

AR and ER interaction with a p21-activated kinase (PAK6).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.