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Article

KLK6‐regulated miRNA networks activate oncogenic pathways in breast cancer subtypes

8 Apr 2016

Abstract excerpt

KLK6 is expressed in normal mammary tissues and is aberrantly regulated in breast cancer. At physiological levels of expression, i.e. those found in normal mammary tissues, KLK6 acts as a tumor suppressor in human breast cancer. However, aberrant overexpression of KLK6 (i.e. 50-100-fold higher than normal), a characteristic of a subset of human breast cancers is associated with increased tumorigenicity...

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PMID: 27093921
DOI: 10.1016/j.molonc.2016.03.008

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