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Article

Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells.

Gastroenterology - 1 Dec 2015

Yu Valen Zhuoyou, Wong Victor Chun-Lam, Dai Wei, Ko Josephine Mun-Yee, Lam Alfred King-Yin, Chan Kwok Wah, Samant Rajeev S, Lung Hong Lok, Shuen Wai Ho, Law Simon, Chan Yuen Piu, Lee Nikki Pui-Yue, Tong Daniel King Hung, Law Tsz Ting, Lee Victor Ho-Fun, Lung Maria Li

Abstract excerpt

BACKGROUND & AIMS: The DnaJ (Hsp40) homolog, subfamily B, member 6 (DNAJB6) is part of a family of proteins that regulates chaperone activities. One of its isoforms, DNAJB6a, contains a nuclear localization signal and regulates β-catenin signaling during breast cancer development. We investigated the role of DNAJB6 in the pathogenesis of esophageal squamous cell carcinoma (ESCC). METHODS: We performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26302489
DOI: 10.1053/j.gastro.2015.08.025

Genes

DNAJB6
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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