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Article

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival

23 Jul 2010

Abstract excerpt

BACKGROUND: Proteins that are required for anchorage-independent survival of tumor cells represent attractive targets for therapeutic intervention since this property is believed to be critical for survival of tumor cells displaced from their natural niches. Anchorage-independent survival is induced by growth factor receptor hyperactivation in many cell types. We aimed to identify molecules that critically...

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PMID: 20668531
DOI: 10.1371/journal.pone.0011729

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