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Article

Protein tyrosine kinase-6 is post-translationally regulated by arginine methylation and ubiquitination.

Cell death & disease - 5 Jun 2026

Jiang Liping, Gilic Milica B, Vlajic Katarina, Bie Wenjun, Kuchay Shafi, Tyner Angela L

Abstract excerpt

Protein tyrosine kinase 6 (PTK6) has context-specific, kinase-dependent and -independent functions in normal cells and cancer. In prostate cells, nuclear PTK6 suppresses growth, while active membrane-associated PTK6 promotes oncogenic signaling. Unlike SRC-family kinases, PTK6 is not modified by lipidation to promote membrane association. Although arginine residues in the PTK6 SH2 domain were previously linked to...

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Topics

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Share to Arginine
Share to Methylation
Share to Prostatic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein-Arginine N-Methyltransferases

Share to Protein Processing, Post-Translational

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Source

Open in PubMed Open full text

Identifiers

PMID: 42248824
DOI: 10.1038/s41419-026-08933-5
PMCID: PMC13458159

Genes

PTK6
PRMT1
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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