Article
AR and ER interaction with a p21-activated kinase (PAK6).
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2002
Lee Suzanne R, Ramos Sharon M, Ko Andrew, Masiello David, Swanson Kenneth D, Lu Michael L, Balk Steven P
Abstract excerpt
A human protein termed p21-activated kinase 6 (PAK6), based on homology to the PAK family of serine/threonine kinases, was cloned as an AR interacting protein. PAK6 was a 75-kDa protein with a predicted N-terminal Cdc42/Rac interactive binding domain and a C-terminal kinase domain. PAK6 bound strongly to GTP-Cdc42 and weakly to GTP-Rac. In contrast to most PAKs, kinase activity was not stimulated by Cdc42 or Rac,...
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