Article
Mapping Drosophila mutations with molecularly defined P element insertions.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2003
Zhai R Grace, Hiesinger P Robin, Koh Tong-Wey, Verstreken Patrik, Schulze Karen L, Cao Yu, Jafar-Nejad Hamed, Norga Koenraad K, Pan Hongling, Bayat Vafa, Greenbaum Michael P, Bellen Hugo J
Abstract excerpt
The isolation of chemically induced mutations in forward genetic screens is one of the hallmarks of Drosophila genetics. However, mapping the corresponding loci and identifying the molecular lesions associated with these mutations are often difficult and labor-intensive. Two mapping methods are most often used in flies: meiotic recombination mapping with marked chromosomes and deficiency mapping. The availability...
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