Article
Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study.
PloS one - 8 Sept 2008
Liu Yao-Zhong, Wilson Scott G, Wang Liang, Liu Xiao-Gang, Guo Yan-Fang, Li Jian, Yan Han, Deloukas Panos, Soranzo Nicole, Chinappen-Horsley Usha, Chinnapen-Horsley Usha, Cervino Alessandra, Cervino Alesandra, Williams Frances M, Xiong Dong-Hai, Zhang Yin-Ping, Jin Tian-Bo, Levy Shawn, Papasian Christopher J, Drees Betty M, Hamilton James J, Recker Robert R, Spector Tim D, Deng Hong-Wen
Abstract excerpt
Osteoporosis, the most prevalent metabolic bone disease among older people, increases risk for low trauma hip fractures (HF) that are associated with high morbidity and mortality. Hip bone size (BS) has been identified as one of the key measurable risk factors for HF. Although hip BS is highly genetically determined, genetic factors underlying the trait are still poorly defined. Here, we performed the first...
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