Article
Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2009
Tang Paul L F, Cheung Ching-Lung, Sham Pak C, McClurg Philip, Lee Bob, Chan Shut-Yan, Smith David K, Tanner Julian A, Su Andrew I, Cheah Kathryn S E, Kung Annie W C, Song You-Qiang
Abstract excerpt
BMD is a heritable trait and risk indicator for osteoporosis. In this study, we used a genome-wide haplotype association mapping (HAM) approach to identify a haplotype block within Cer1 that partitions inbred mice strains into high and low BMD groups. A cohort of 1083 high and low BMD human subjects were studied, and a nonsynonymous SNP (rs3747532) in human CER1 was identified to be associated with increased risk...
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