Article
Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
PLoS genetics - 8 Jan 2010
Guo Yan, Tan Li-Jun, Lei Shu-Feng, Yang Tie-Lin, Chen Xiang-Ding, Zhang Feng, Chen Yuan, Pan Feng, Yan Han, Liu Xiaogang, Tian Qing, Zhang Zhi-Xin, Zhou Qi, Qiu Chuan, Dong Shan-Shan, Xu Xiang-Hong, Guo Yan-Fang, Zhu Xue-Zhen, Liu Shan-Lin, Wang Xiang-Li, Li Xi, Luo Yi, Zhang Li-Shu, Li Meng, Wang Jin-Tang, Wen Ting, Drees Betty, Hamilton James, Papasian Christopher J, Recker Robert R, Song Xiao-Ping, Cheng Jing, Deng Hong-Wen
Abstract excerpt
Osteoporosis is a major public health problem. It is mainly characterized by low bone mineral density (BMD) and/or low-trauma osteoporotic fractures (OF), both of which have strong genetic determination. The specific genes influencing these phenotypic traits, however, are largely unknown. Using the Affymetrix 500K array set, we performed a case-control genome-wide association study (GWAS) in 700 elderly Chinese...
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