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A multiethnic whole genome sequencing study to identify novel loci for bone mineral density.

Human molecular genetics - 31 Mar 2022

Greenbaum Jonathan, Su Kuan-Jui, Zhang Xiao, Liu Yong, Liu Anqi, Zhao Lan-Juan, Luo Zhe, Tian Qing, Shen Hui, Deng Hong-Wen

Abstract excerpt

At present, there have only been a few DNA sequencing-based studies to explore the genetic determinants of bone mineral density (BMD). We carried out the largest whole genome sequencing analysis to date for femoral neck and spine BMD (n = 4981), with one of the highest average sequencing depths implemented thus far at 22×, in a multiethnic sample (58% Caucasian and 42% African American) from the Louisiana...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34673960
DOI: 10.1093/hmg/ddab305
PMCID: PMC8976433

Genes

ESR1
IGF2
LYSMD4
MAML2
NFIB
PDE4D
PIGN
SIPA1
TRAF3IP2
WNT16
ZNF423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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