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Article

Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein.

The Journal of biological chemistry - 14 Nov 2008

Bartonova Vanda, Igonet Sébastien, Sticht Jana, Glass Bärbel, Habermann Anja, Vaney Marie-Christine, Sehr Peter, Lewis Joe, Rey Felix A, Kraüsslich Hans-Georg

Abstract excerpt

Morphogenesis of infectious HIV-1 involves budding of immature virions followed by proteolytic disassembly of the Gag protein shell and subsequent assembly of processed capsid proteins (CA) into the mature HIV-1 core. The dimeric interface between C-terminal domains of CA (C-CA) has been shown to be important for both immature and mature assemblies. We previously reported a CA-binding peptide (CAI) that blocks...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18772135
DOI: 10.1074/jbc.M804230200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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