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Article

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.

PLoS pathogens - 1 Jan 2012

Price Amanda J, Fletcher Adam J, Schaller Torsten, Elliott Tom, Lee KyeongEun, KewalRamani Vineet N, Chin Jason W, Towers Greg J, James Leo C

Abstract excerpt

The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with which to interact with cellular cofactors....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22956906
DOI: 10.1371/journal.ppat.1002896
PMCID: PMC3431306

Genes

CPSF6
TNPO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22956906-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.PMID 22956906Read ↗

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Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage <i>In Vivo</i>Semantic proximity Read ↗

HIV-1 capsid and viral DNA integrationSemantic proximity Read ↗

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