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Article

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

PLoS pathogens - 1 Oct 2014

Price Amanda J, Jacques David A, McEwan William A, Fletcher Adam J, Essig Sebastian, Chin Jason W, Halambage Upul D, Aiken Christopher, James Leo C

Abstract excerpt

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), and the mechanistic basis for how these ligands influence infection is not well understood. Here we show that a multi-subunit interface formed exclusively within CA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25356722
DOI: 10.1371/journal.ppat.1004459
PMCID: PMC4214760

Genes

CPSF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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